Anti-ABCG2 / CD338 Antibody
417.46 $ – 242.68 $
Immunofluorescence staining of A549 cells with rabbit anti-ABCG2 antibody IGX-40491
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-40491
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PMID:11306452, PMID:12958161, PMID:19506252, PMID:20705604, PMID:28554189, PMID:30405239, PMID:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PMID:20705604, PMID:23189181). Also mediates the efflux of sphingosine-1-P from cells (PMID:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PMID:19506252, PMID:20368174, PMID:22132962, PMID:31003562). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate . Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PMID:12682043, PMID:28554189, PMID:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk . Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability . Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PMID:11306452, PMID:12477054, PMID:15670731, PMID:18056989, PMID:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus . May play a role in early stem cell self-renewal by blocking differentiation . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IF |
| Recommended Dilutions | IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human ATP-binding cassette sub-family G member 2 protein (296-371AA) |
| Specificity | ABCG2 antibody detects endogenous level of ABCG2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
Related Products
-
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page