Anti-ADAM10 / CD156c Antibody
419.28 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human colon cancer with rabbit anti-ADAM10 antibody IGX-43599 at dilution 1:100.
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Catalog No
IGX-43599
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77′ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PMID:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PMID:26686862, PMID:11786905, PMID:29224781). Contributes to the normal cleavage of the cellular prion protein (PMID:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PMID:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis . Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PMID:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PMID:19114711, PMID:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 . Enhances the cleavage of CHL1 by BACE1 . Cleaves NRCAM . Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PMID:24990881). Involved in the development and maturation of glomerular and coronary vasculature . During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions . May regulate the EFNA5-EPHA3 signaling (PMID:16239146). (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA) |
| Specificity | ADAM10 antibody detects endogenous level of ADAM10 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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