Anti-AHR Antibody
417.46 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human brain tissue with rabbit anti-AHR antibody IGX-44111 at dilution 1:100.
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Catalog No
IGX-44111
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PMID:10395741, PMID:28602820, PMID:7961644, PMID:23275542, PMID:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PMID:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PMID:7961644). Involved in cell-cycle regulation (PMID:12213388). Likely to play an important role in the development and maturation of many tissues (PMID:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PMID:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5′-TGCGTG-3′ within the dioxin response element (DRE) of target gene promoters and activates their transcription (PMID:28602820). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Aryl hydrocarbon receptor protein (126-353AA) |
| Specificity | AHR antibody detects endogenous level of AHR protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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