Anti-AKT3 Antibody
419.42 $ – 243.82 $
Immunoprecipitating AKT3 in mouse brain whole cell lysate
Lane 1: Rabbit control IgG (1µg) instead of anti-AKT3 antibody IGX-45678 in mouse brain whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: anti-AKT3 antibody IGX-45678 (6µg) + Mouse brain whole cell lysate (500µg)
Lane 3: Mouse brain whole cell lysate (10µg)
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-45678
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, IP |
| Recommended Dilutions | IP: 1:200-1:2000 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human RAC-gamma serine/threonine-protein kinase protein (1-164AA) |
| Specificity | AKT3 antibody detects endogenous level of AKT3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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