Anti-ALKBH3 Antibody
418.43 $ – 243.25 $
Immunohistochemical staining of human testis tissue with rabbit anti-ALKBH3 antibody IGX-43970 at dilution 1:100.
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Catalog No
IGX-43970
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PMID:12486230, PMID:12594517, PMID:16174769, PMID:26863196, PMID:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PMID:12486230, PMID:12594517, PMID:16174769, PMID:25944111). Has a strong preference for single-stranded DNA (PMID:12486230, PMID:12594517, PMID:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PMID:22055184). Also acts on RNA (PMID:12594517, PMID:16174769, PMID:26863196, PMID:26863410, PMID:16858410). Demethylates N1-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5′-untranslated regions (UTRs) and in the vicinity of start codons (PMID:26863196, PMID:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PMID:22055184, PMID:16858410). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 protein (1-170AA) |
| Specificity | ALKBH3 antibody detects endogenous level of ALKBH3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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