Anti-APLN Antibody
419.42 $ – 243.82 $
Immunohistochemistry of paraffin-embedded human placenta tissue with rabbit anti-APLN antibody IGX-40799
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Catalog No
IGX-40799
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Endogenous ligand for the apelin receptor (APLNR) (PMID:10525157). Drives internalization of the apelin receptor . Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR . Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis . Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates . Plays a role in early coronary blood vessels formation . Mediates myocardial contractility in an ERK1/2-dependent manner . May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior . (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PMID:11090199). Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PMID:11090199). Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PMID:11090199). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:10-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence from Human Apelin protein |
| Specificity | APLN antibody detects endogenous level of APLN protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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