Anti-Arg2 / Arginase 2 Antibody
419.18 $ – 243.68 $
Western blot
All lanes: Arg2 antibody at 10µg/mL + Jurkat whole cell lysate
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Catalog No
IGX-48218
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4+ and CD8+ T cells (PMID:27745970, PMID:25009204). May suppress inflammation-related signaling in asthmatic airway epithelium (PMID:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (PMID:27074721). May play a role in promoting prenatal immune suppression . Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PMID:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PMID:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity . |
| Host Species | Rabbit |
| Species Reactivity | Mouse, Human |
| Applications | ELISA, WB |
| Recommended Dilutions | WB: 1:500-1:2000 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Mouse Arginase-2, mitochondrial protein (23-354AA) |
| Specificity | Arg2 antibody detects endogenous level of Arg2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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