Anti-ATIC Antibody
421.25 $ – 244.89 $
Immunohistochemistry of paraffin-embedded human lymph node tissue with rabbit anti-ATIC antibody IGX-43610 at dilution 1:100.
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Catalog No
IGX-43610
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PMID:11948179, PMID:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PMID:9378707, PMID:11948179, PMID:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PMID:10985775). Also catalyzes the cyclization of FAICAR to IMP (PMID:11948179, PMID:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PMID:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PMID:25687571). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Bifunctional purine biosynthesis protein PURH protein (301-592AA) |
| Specificity | ATIC antibody detects endogenous level of ATIC protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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