Anti-BLK Antibody
389.62 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human breast cancer with rabbit anti-BLK antibody IGX-42165
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Catalog No
IGX-42165
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling . B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors . Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation . Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor . Specifically binds and phosphorylates CD79A at ‘Tyr-188’and ‘Tyr-199’, as well as CD79B at ‘Tyr-196’ and ‘Tyr-207’ . Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PMID:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation . Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation . In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PMID:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PMID:30356214). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA) |
| Specificity | BLK antibody detects endogenous level of BLK protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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