Anti-BTRC Antibody
419.70 $ – 243.98 $
Western Blot
analysis of K562 whole cell lysate
All lanes: BTRC antibody at 2.8µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-48080
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PMID:10066435, PMID:10497169, PMID:10644755, PMID:10835356, PMID:11238952, PMID:11359933, PMID:11994270, PMID:12791267, PMID:12902344, PMID:14603323, PMID:14681206, PMID:14988407, PMID:15448698, PMID:15917222, PMID:16371461, PMID:25503564, PMID:25704143, PMID:9859996, PMID:22087322). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PMID:12077367, PMID:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PMID:10835356, PMID:11238952, PMID:14681206, PMID:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PMID:10066435, PMID:10497169, PMID:10644755). Ubiquitination of NFKBIA occurs at ‘Lys-21’ and ‘Lys-22’ (PMID:10066435). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PMID:25704143, PMID:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 . Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PMID:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PMID:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PMID:21258371, PMID:18354482). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:2000-1:10000, IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA) |
| Specificity | BTRC antibody detects endogenous level of BTRC protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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