Anti-CALHM1 Antibody
391.32 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human liver cancer with rabbit anti-CALHM1 antibody IGX-42199
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-42199
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes . Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways . Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) . Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration (PMID:22711817, PMID:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions (PMID:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PMID:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PMID:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner (PMID:18585350). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Calcium homeostasis modulator protein 1 protein (202-346AA) |
| Specificity | CALHM1 antibody detects endogenous level of CALHM1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
Related Products
-
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page -
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page -
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page -
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page