Anti-CASP14 / Caspase 14 Antibody
419.18 $ – 243.68 $
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, A431 cells, A549 cells, A375 cells, Primary antibody: CASP14 antibody at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Catalog No
IGX-52180
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PMID:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin . In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PMID:16854378, PMID:19960512). Involved in processing of prosaposin in the epidermis . May be involved in retinal pigment epithelium cell barrier function (PMID:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PMID:24743736). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB |
| Recommended Dilutions | ELISA: 1:2000-1:5000, WB: 1:500-1:2000 |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human CASP14 |
| Specificity | CASP14 antibody detects endogenous level of CASP14 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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