Anti-CASP8 / Caspase 8 Antibody
393.17 $ – 244.89 $
Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma using CASP8 antibody
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Catalog No
IGX-52189
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PMID:23516580, PMID:8681376, PMID:8681377, PMID:9006941, PMID:9184224). Binding to the adapter molecule FADD recruits it to either receptor (PMID:8681376, PMID:8681377). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PMID:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PMID:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PMID:9184224). Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PMID:9006941). May participate in the Granzyme B (GZMB) apoptotic pathways (PMID:8755496). Cleaves PARP1 (PMID:8681376). Cleaves RIPK1 at ‘Asp-324’, which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PMID:31827280, PMID:31827281). Isoform 5: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. Isoform 6: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. Isoform 7: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PMID:12010809). Isoform 8: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Recommended Dilutions | WB: 1:1000-2000, IHC: 1:50-100 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Protein |
| Specificity | CASP8 antibody detects endogenous level of CASP8 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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