Anti-CDK5RAP2 Antibody
389.62 $ – 242.68 $
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Catalog No
IGX-52402
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation . Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PMID:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PMID:29162697). Required for the recruitment of AKAP9 to centrosomes (PMID:29162697). Plays a role in neurogenesis . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | IHC, ELISA |
| Recommended Dilutions | IHC: 1:100-1:300, ELISA: 1:20000 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide derived from the N-terminal region of human CDK5 Activator-binding C48. |
| Specificity | CDK5RAP2 antibody detects endogenous level of CDK5RAP2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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