Anti-CDK5RAP3 Antibody
418.43 $ – 243.25 $
IHC staining of paraffin-embedded Human thyroid cancer tissue
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Catalog No
IGX-52403
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PMID:23152784, PMID:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PMID:17785205, PMID:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PMID:12054757, PMID:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PMID:15790566, PMID:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PMID:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PMID:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PMID:21283629). Required for liver development . (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | ELISA: 1:1000-1:2000, WB: 1:200-1:1000, IHC: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human CDK5RAP3 |
| Specificity | CDK5RAP3 antibody detects endogenous level of CDK5RAP3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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