Anti-CEACAM6 / CD66c Antibody
419.28 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human colon cancer with rabbit anti-CEACAM6 antibody IGX-44495 at dilution 1:100.
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Catalog No
IGX-44495
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PMID:2803308, PMID:2022629, PMID:1378450, PMID:8776764, PMID:11590190, PMID:10910050, PMID:14724575, PMID:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PMID:2022629, PMID:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PMID:2803308, PMID:2022629, PMID:8776764, PMID:11590190, PMID:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PMID:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PMID:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PMID:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PMID:10910050, PMID:14724575). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 protein (35-320AA) |
| Specificity | CEACAM6 antibody detects endogenous level of CEACAM6 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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