Anti-CENPA Antibody
391.72 $ – 243.98 $
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Catalog No
IGX-52456
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PMID:7962047, PMID:9024683, PMID:11756469, PMID:14667408, PMID:15702419, PMID:15475964, PMID:15282608, PMID:17651496, PMID:19114591, PMID:27499292, PMID:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PMID:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PMID:27499292, PMID:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PMID:15475964, PMID:15282608, PMID:26878239, PMID:20739937, PMID:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PMID:11756469, PMID:14667408, PMID:18072184, PMID:23818633, PMID:25556658, PMID:27499292). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | IHC, IF, ELISA |
| Recommended Dilutions | IHC: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:10000 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide derived from human CENP-A around the non-phosphorylation site of S7. |
| Specificity | CENPA antibody detects endogenous level of CENPA protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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