Anti-CHCHD4 Antibody
417.46 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human liver tissue with rabbit anti-CHCHD4 antibody IGX-41662
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-41662
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PMID:26004228). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7 (PMID:16185709, PMID:26387864, PMID:19182799, PMID:21059946, PMID:23186364, PMID:23676665, PMID:30885959). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS (PMID:30885959). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PMID:16185709, PMID:19182799, PMID:21059946, PMID:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PMID:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PMID:26387864). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Mitochondrial intermembrane space import and assembly protein 40 protein (1-142AA) |
| Specificity | CHCHD4 antibody detects endogenous level of CHCHD4 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
Related Products
-
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page