Anti-Cleaved-CASP1 (M211) Antibody
391.32 $ – 243.74 $
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Catalog No
IGX-52573
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PMID:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PMID:20197547). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | IHC, ELISA |
| Recommended Dilutions | IHC: 1:100-1:300, ELISA: 1:20000 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide derived from the internal region of human Caspase-1. |
| Specificity | Cleaved-CASP1 (M211) antibody detects endogenous level of Cleaved-CASP1 (M211) protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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