Anti-CLU / Clusterin Antibody
419.70 $ – 243.98 $
IHC staining of paraffin-embedded Human liver cancer tissue
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Catalog No
IGX-52597
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Isoform 1: Functions as extracellular chaperone that prevents aggregation of non native proteins (PMID:11123922, PMID:19535339). Prevents stress-induced aggregation of blood plasma proteins (PMID:11123922, PMID:12176985, PMID:17260971, PMID:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PMID:12047389, PMID:17412999, PMID:17407782). Does not require ATP (PMID:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PMID:11123922). Does not refold proteins by itself (PMID:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PMID:21505792). Protects cells against apoptosis and against cytolysis by complement (PMID:2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PMID:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PMID:20068069). Modulates NF-kappa-B transcriptional activity (PMID:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PMID:16113678, PMID:17689225). Plays a role in the regulation of cell proliferation (PMID:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PMID:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PMID:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 . Plays a role in the clearance of immune complexes that arise during cell injury . Isoform 6: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Isoform 4: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PMID:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PMID:21567405). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA: 1:2000-1:5000, IHC: 1:25-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human CLU |
| Specificity | CLU antibody detects endogenous level of CLU protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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