Anti-CPEB3 Antibody
418.43 $ – 243.25 $
Immunofluorescence staining of HeLa cells with rabbit anti-CPEB3 antibody IGX-40685
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Catalog No
IGX-40685
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator . In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3′-UTR, but binds to a U-rich loop within a stem-loop structure . Required for the consolidation and maintenance of hippocampal-based long term memory . In the basal state, binds to the mRNA 3′-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation . Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B . When activated, acts as a translational activator of GRIA1 and GRIA2 . In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation . Binds to the 3′-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception . Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation . Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PMID:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PMID:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PMID:26398195). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IF |
| Recommended Dilutions | IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Cytoplasmic polyadenylation element-binding protein 3 protein (414-525AA) |
| Specificity | CPEB3 antibody detects endogenous level of CPEB3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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