Anti-CREBBP Antibody
417.46 $ – 242.68 $
IHC staining of paraffin-embedded Human cervical cancer tissue
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Catalog No
IGX-52718
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Acetylates histones, giving a specific tag for transcriptional activation (PMID:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PMID:10490106, PMID:11154691, PMID:12738767, PMID:12929931, PMID:9707565, PMID:24207024, PMID:28790157, PMID:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PMID:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PMID:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PMID:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PMID:28790157). Acetylates FBL, preventing methylation of ‘Gln-105’ of histone H2A (H2AQ104me) (PMID:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PMID:25514493). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA: 1:500-1:5000, IHC: 1:5-1:20 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human CREBBP |
| Specificity | CREBBP antibody detects endogenous level of CREBBP protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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