Anti-CYLD Antibody
418.43 $ – 243.25 $
Immunohistochemistry of paraffin-embedded human breast cancer with rabbit anti-CYLD antibody IGX-44610 at dilution 1:100.
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Catalog No
IGX-44610
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Deubiquitinase that specifically cleaves ‘Lys-63’- and linear ‘Met-1’-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PMID:18636086, PMID:26670046, PMID:27458237, PMID:26997266, PMID:27591049, PMID:29291351, PMID:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PMID:12917689, PMID:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PMID:12917690). Negative regulator of Wnt signaling (PMID:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PMID:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PMID:18222923, PMID:20194890). Required for normal cell cycle progress and normal cytokinesis (PMID:17495026, PMID:19893491). Inhibits nuclear translocation of NF-kappa-B (PMID:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PMID:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells . Negatively regulates TNFRSF11A signaling and osteoclastogenesis . Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation . Ability to remove linear (‘Met-1’-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PMID:26997266, PMID:26670046, PMID:27458237, PMID:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PMID:26997266). Involved in TNF-alpha-induced necroptosis by removing linear (‘Met-1’-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 . Removes ‘Lys-63’ linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PMID:29291351). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Ubiquitin carboxyl-terminal hydrolase CYLD protein (269-435AA) |
| Specificity | CYLD antibody detects endogenous level of CYLD protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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