Anti-CYP2B6 Antibody
418.43 $ – 243.25 $
Immunohistochemistry of paraffin-embedded human liver tissue with rabbit anti-CYP2B6 antibody IGX-44668 at dilution 1:100.
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Catalog No
IGX-44668
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PMID:21289075, PMID:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH–hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PMID:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PMID:21289075, PMID:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PMID:11695850, PMID:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PMID:11695850). Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Cytochrome P450 2B6 protein (250-343AA) |
| Specificity | CYP2B6 antibody detects endogenous level of CYP2B6 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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