Anti-CYP3A4 Antibody
419.28 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human small intestine tissue with rabbit anti-CYP3A4 antibody IGX-47997 at dilution 1:100
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Catalog No
IGX-47997
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PMID:10681376, PMID:11093772, PMID:11555828, PMID:14559847, PMID:12865317, PMID:15373842, PMID:15764715, PMID:20702771, PMID:19965576, PMID:21490593, PMID:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH–hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PMID:2732228, PMID:14559847, PMID:12865317, PMID:15373842, PMID:15764715, PMID:21576599, PMID:21490593). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PMID:11555828, PMID:14559847, PMID:12865317). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PMID:2732228, PMID:15373842, PMID:15764715, PMID:22773874). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PMID:2732228, PMID:15373842, PMID:15764715). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PMID:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PMID:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PMID:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PMID:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PMID:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PMID:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PMID:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PMID:10759686). Hydroxylates antimalarial drug quinine (PMID:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PMID:11695850). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:200-1:5000, IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Cytochrome P450 3A4 protein (259-441AA) |
| Specificity | CYP3A4 antibody detects endogenous level of CYP3A4 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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