Anti-CYP4A11 Antibody
390.58 $ – 243.28 $
Immunohistochemistry of paraffin-embedded human liver cancer with rabbit anti-CYP4A11 antibody IGX-42106
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Catalog No
IGX-42106
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PMID:7679927, PMID:1739747, PMID:8914854, PMID:10553002, PMID:10660572, PMID:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PMID:7679927, PMID:1739747, PMID:8914854, PMID:10553002, PMID:10660572, PMID:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PMID:10553002, PMID:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PMID:7679927, PMID:1739747, PMID:8914854, PMID:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PMID:10620324, PMID:10660572, PMID:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PMID:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PMID:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PMID:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PMID:18065749). Has little activity toward prostaglandins A1 and E1 (PMID:7679927). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Cytochrome P450 4A11 protein (1-200AA) |
| Specificity | CYP4A11 antibody detects endogenous level of CYP4A11 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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