Anti-DCP2 Antibody
418.43 $ – 243.25 $
Immunohistochemistry of paraffin-embedded human testis tissue with rabbit anti-DCP2 antibody IGX-41508
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Catalog No
IGX-41508
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PMID:12417715, PMID:12218187, PMID:12923261, PMID:21070968, PMID:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5′-phosphorylated mRNA fragment and 7m-GDP (PMID:12486012, PMID:12923261, PMID:21070968, PMID:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PMID:14527413). Plays a role in replication-dependent histone mRNA degradation (PMID:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PMID:21070968). Has no activity towards a cap structure lacking an RNA moiety (PMID:21070968). The presence of a N6-methyladenosine methylation at the second transcribed position of mRNAs (N6,2′-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PMID:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PMID:26098573). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human m7GpppN-mRNA hydrolase protein (1-385AA) |
| Specificity | DCP2 antibody detects endogenous level of DCP2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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