Anti-DDB1 Antibody
418.48 $ – 243.28 $
Immunohistochemistry of paraffin-embedded human kidney tissue with rabbit anti-DDB1 antibody IGX-43561
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Catalog No
IGX-43561
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PMID:15448697, PMID:14739464, PMID:16260596, PMID:16482215, PMID:17079684, PMID:16407242, PMID:16407252, PMID:16940174). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PMID:15448697, PMID:16260596, PMID:16407242, PMID:16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PMID:15448697, PMID:16260596, PMID:16407242, PMID:16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PMID:14739464, PMID:16407252, PMID:16482215, PMID:17079684, PMID:25043012, PMID:25108355, PMID:18332868, PMID:18381890, PMID:19966799, PMID:22118460, PMID:28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PMID:14739464, PMID:16407252, PMID:16482215, PMID:17079684, PMID:25043012, PMID:25108355, PMID:18332868, PMID:18381890, PMID:19966799, PMID:22118460). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PMID:16678110, PMID:17041588, PMID:16473935, PMID:18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PMID:16678110, PMID:17041588, PMID:16473935, PMID:18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PMID:15882621). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PMID:17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PMID:12732143). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PMID:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human DNA damage-binding protein 1 protein (741-943AA) |
| Specificity | DDB1 antibody detects endogenous level of DDB1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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