Anti-DGKZ Antibody
417.46 $ – 242.68 $
Immunofluorescence staining of HeLa cells with rabbit anti-DGKZ antibody IGX-40428
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Catalog No
IGX-40428
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PMID:9159104, PMID:15544348, PMID:18004883, PMID:19744926, PMID:22108654, PMID:22627129, PMID:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PMID:9159104, PMID:15544348, PMID:18004883, PMID:19744926, PMID:22108654, PMID:22627129, PMID:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PMID:9159104, PMID:19744926, PMID:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PMID:15544348, PMID:19744926, PMID:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol . By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PMID:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IF |
| Recommended Dilutions | IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Diacylglycerol kinase zeta protein (11-152AA) |
| Specificity | DGKZ antibody detects endogenous level of DGKZ protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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