Anti-EHD3 Antibody
418.43 $ – 243.25 $
Immunohistochemistry of paraffin-embedded human brain tissue with rabbit anti-EHD3 antibody IGX-44244 at dilution 1:100.
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Catalog No
IGX-44244
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PMID:25686250). In vitro causes tubulation of endocytic membranes (PMID:24019528). Binding to phosphatidic acid induces its membrane tubulation activity . Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PMID:16251358, PMID:17233914, PMID:19139087, PMID:23781025). Involved in the recycling of internalized D1 dopamine receptor (PMID:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PMID:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction . In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function . Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PMID:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing . Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PMID:25686250). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human EH domain-containing protein 3 protein (269-498AA) |
| Specificity | EHD3 antibody detects endogenous level of EHD3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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