Anti-ERBB2 / HER2 Antibody
391.46 $ – 243.82 $
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-53264
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5′-TCAAATTC-3′ sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | IF, ELISA |
| Recommended Dilutions | IF: 1:200-1:1000, ELISA: 1:5000 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide derived from human Neu around the non-phosphorylation site of Y1139. |
| Specificity | ERBB2 antibody detects endogenous level of ERBB2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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