Anti-EXD2 Antibody
419.42 $ – 243.82 $
Western Blot
analysis of Mouse brain tissue, Mouse stomach tissue
All lanes: EXD2 antibody at 2.8µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-48063
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Exonuclease that has both 3′-5′ exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PMID:29335528, PMID:31127291). In presence of Mg2+, only shows 3′-5′ exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn2+ (PMID:29335528, PMID:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PMID:29335528). Also involved in the response to DNA damage (PMID:26807646, PMID:31255466). Acts as 3′-5′ exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PMID:20603073, PMID:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3′-5′ exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PMID:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PMID:31255466). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | WB: 1:2000-1:10000, IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Exonuclease 3′-5′ domain-containing protein 2 protein (137-245AA) |
| Specificity | EXD2 antibody detects endogenous level of EXD2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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