Anti-FAN1 Antibody
418.48 $ – 243.28 $
Western Blot
analysis of PC-3 whole cell lysate
All lanes: FAN1 antibody at 5.3µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-50853
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PMID:20603015, PMID:20603016, PMID:20603073, PMID:20671156, PMID:24981866, PMID:25430771). Not involved in DNA double-strand breaks resection (PMID:20603015, PMID:20603016). Acts as a 5′-3′ exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3′-flap annealing until it reaches and unhooks the ICL (PMID:25430771). Acts at sites that have a 5′-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3′ flap (PMID:25430771). Also has endonuclease activity toward 5′-flaps (PMID:20603015, PMID:20603016, PMID:24981866). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | WB: 1:500-1:5000, IHC: 1:200-1:500 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA) |
| Specificity | FAN1 antibody detects endogenous level of FAN1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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