Anti-FOXC1 Antibody
418.43 $ – 243.25 $
Western Blot
analysis of MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: FOXC1 antibody at 3µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-49625
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PMID:11782474, PMID:15299087, PMID:15684392, PMID:16492674, PMID:27907090, PMID:14506133, PMID:14578375, PMID:15277473, PMID:16449236, PMID:17210863, PMID:19793056, PMID:19279310, PMID:25786029, PMID:27804176). Acts either as a transcriptional activator or repressor (PMID:11782474). Binds to the consensus binding site 5′-[G/C][A/T]AAA[T/C]AA[A/C]-3′ in promoter of target genes (PMID:7957066, PMID:11782474, PMID:12533514, PMID:14506133, PMID:19793056, PMID:27804176). Upon DNA-binding, promotes DNA bending (PMID:7957066, PMID:14506133). Acts as a transcriptional coactivator (PMID:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification . Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PMID:26565916). Regulates FOXO1 through binding to a conserved element, 5′-GTAAACAAA-3′ in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PMID:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity . Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PMID:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PMID:20406990, PMID:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression . Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PMID:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression . May function as a tumor suppressor (PMID:12408963). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IF |
| Recommended Dilutions | WB: 1:500-1:5000, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Forkhead box protein C1 protein (1-79AA) |
| Specificity | FOXC1 antibody detects endogenous level of FOXC1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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