Anti-FOXO1 (Ab-256) / FKHR Antibody
419.42 $
Western blot analysis of extracts from HeLa cells FOXO1 (FKHR) antibody.
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Catalog No
IGX-53503
Supplier
ImuGeX
Size
100 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PMID:10358076, PMID:12228231, PMID:15220471, PMID:15890677, PMID:18356527, PMID:19221179, PMID:20543840, PMID:21245099). Binds to the insulin response element (IRE) with consensus sequence 5′-TT[G/A]TTTTG-3′ and the related Daf-16 family binding element (DBE) with consensus sequence 5′-TT[G/A]TTTAC-3′ (PMID:10358076). Activity suppressed by insulin (PMID:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass . Orchestrates the endocrine function of the skeleton in regulating glucose metabolism . lso acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation . Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity . Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP . In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1 . Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PMID:18356527, PMID:19221179). Promotes neural cell death (PMID:18356527). Mediates insulin action on adipose tissue . Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake . Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells . Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PMID:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling . |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:500-1:1000, IHC: 1:50-1:200, IF: 1:100-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence around AA 254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A. |
| Specificity | FOXO1 (Ab-256) antibody detects endogenous level of FOXO1 (Ab-256) protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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