Anti-GBA Antibody
417.46 $ – 242.68 $
Western Blot
analysis of MCF-7 whole cell lysate, HepG2 whole cell lysate, HeLa whole cell lysate
All lanes: GBA antibody at 3.6µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-51097
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PMID:9201993, PMID:24211208, PMID:15916907). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PMID:27378698). Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (PMID:19279011). Also plays a role in cholesterol metabolism (PMID:24211208, PMID:26724485). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PMID:24211208, PMID:26724485). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (PMID:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PMID:26724485). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (PMID:24211208, PMID:26724485). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | WB: 1:500-1:5000, IHC: 1:500-1:1000 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Glucosylceramidase protein (215-343AA) |
| Specificity | GBA antibody detects endogenous level of GBA protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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