Anti-GCKR / Glucokinase regulatory protein Antibody
419.70 $ – 243.98 $
IHC staining of paraffin-embedded Human thyroid cancer tissue
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Catalog No
IGX-53616
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PMID:23621087, PMID:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PMID:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PMID:23621087, PMID:23733961). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA: 1:1000-1:2000, IHC: 1:25-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human GCKR |
| Specificity | GCKR antibody detects endogenous level of GCKR protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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