Anti-GLI2 Antibody
417.46 $ – 242.68 $
Immunohistochemical staining with rabbit anti-GLI2 antibody IGX-48908 at 1:100 in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Catalog No
IGX-48908
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Functions as transcription regulator in the hedgehog (Hh) pathway (PMID:18455992, PMID:26565916). Functions as transcriptional activator (PMID:9557682, PMID:19878745, PMID:24311597). May also function as transcriptional repressor . Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PMID:15994174, PMID:20685856). Isoform 1: Involved in the smoothened (SHH) signaling pathway. Isoform 2: Involved in the smoothened (SHH) signaling pathway. Isoform 3: Involved in the smoothened (SHH) signaling pathway. Isoform 4: Involved in the smoothened (SHH) signaling pathway. Isoform 1: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5′-GAACCACCCA-3′ which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PMID:9557682). Isoform 2: (Microbial infection) Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5′-GAACCACCCA-3′ which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PMID:9557682). Isoform 3: (Microbial infection) Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5′-GAACCACCCA-3′ which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PMID:9557682). Isoform 4: (Microbial infection) Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5′-GAACCACCCA-3′ which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PMID:9557682). Isoform 5: Acts as a transcriptional repressor. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | WB: 1:500-1:2000, IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence from Human Zinc finger protein GLI2 protein (2-20AA) |
| Specificity | GLI2 antibody detects endogenous level of GLI2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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