Anti-GLUL / Glutamine synthetase Antibody
419.70 $
Western blot analysis of extracts from Rat and Mouse brain tissue and C6 cells using Glutamine Synthetase antibody.
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Catalog No
IGX-53693
Supplier
ImuGeX
Size
100 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PMID:30158707, PMID:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia . Essential for proliferation of fetal skin fibroblasts (PMID:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PMID:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PMID:30158707). Plays a role in ribosomal 40S subunit biogenesis (PMID:26711351). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Recommended Dilutions | WB: 1:500-1:1000 |
| Conjugate | Unconjugated |
| Immunogen | Peptide sequence around AA 365~369 (G-D-E-P-F) derived from Human Glutamine Synthetase |
| Specificity | GLUL antibody detects endogenous level of GLUL protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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