Anti-H2AFB1 Antibody
417.46 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human liver tissue with rabbit anti-H2AFB1 antibody IGX-43694 at dilution 1:100.
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Catalog No
IGX-43694
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PMID:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PMID:15257289, PMID:16287874, PMID:16957777, PMID:17591702, PMID:17726088, PMID:18329190, PMID:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PMID:15257289, PMID:16957777, PMID:17591702, PMID:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PMID:17591702, PMID:24753410). They associate with spliceosome components and are required for mRNA splicing (PMID:22795134). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Histone H2A-Bbd type 1 protein (1-115AA) |
| Specificity | H2AFB1 antibody detects endogenous level of H2AFB1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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