Anti-HTR2A / 5-hydroxytryptamine receptor 2A Antibody
389.62 $ – 242.68 $
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Catalog No
IGX-54044
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PMID:1330647, PMID:18703043, PMID:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PMID:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PMID:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PMID:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores (PMID:18703043, PMID:28129538). Affects neural activity, perception, cognition and mood (PMID:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | IHC, IF, ELISA |
| Recommended Dilutions | IHC: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:5000 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide derived from the C-terminal region of human SR-2A. |
| Specificity | HTR2A antibody detects endogenous level of HTR2A protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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