Anti-HTR2B Antibody
389.62 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human prostate tissue with rabbit anti-HTR2B antibody IGX-42128
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Catalog No
IGX-42128
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PMID:8143856, PMID:7926008, PMID:8078486, PMID:8882600, PMID:18703043, PMID:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PMID:8143856, PMID:7926008, PMID:8078486, PMID:12970106, PMID:18703043, PMID:23519210, PMID:23519215, PMID:24357322, PMID:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PMID:8143856, PMID:8078486, PMID:8882600, PMID:23519215, PMID:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PMID:23519215, PMID:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores (PMID:8143856, PMID:8078486, PMID:8882600, PMID:18703043, PMID:23519215, PMID:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain . Plays a role in the regulation of behavior, including impulsive behavior (PMID:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human 5-hydroxytryptamine receptor 2B protein (382-481AA) |
| Specificity | HTR2B antibody detects endogenous level of HTR2B protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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