Anti-IPO5 Antibody
438.51 $
Western blot analysis of extracts of various cell lines and tissues using IPO5 antibody.
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Catalog No
IGX-5257
Supplier
ImuGeX
Size
100 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF |
| Recommended Dilutions | WB: 1:500-1:2000. IHC: 1:50-1:200. IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant protein of human IPO5 |
| Specificity | IPO5 antibody detects endogenous levels of IPO5 protein. |
Product Properties
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Formulation | Liquid |
| Purification | Affinity purification |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions. |
Target Gene
NA
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