Anti-KAT2A Antibody
417.46 $ – 242.68 $
Immunohinstochemical staining with rabbit anti-KAT2A antibody IGX-45133 at 1:300 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-45133
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PMID:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on ‘Lys-79’ (H3K79succ), with a maximum frequency around the transcription start sites of genes (PMID:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PMID:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PMID:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PMID:17301242, PMID:19103755, PMID:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PMID:17301242, PMID:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PMID:17301242, PMID:19103755, PMID:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PMID:29973595, PMID:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling . Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at ‘Lys-9’ (H3K9ac), leading to promote IL2 expression . Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at ‘Lys-9’ (H3K9ac) . Regulates embryonic stem cell (ESC) pluripotency and differentiation . Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PMID:17301242, PMID:27796307, PMID:29174768). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PMID:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PMID:27796307). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on ‘Lys-91’ (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PMID:31542297). (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:200-1:500 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Histone acetyltransferase KAT2A protein (302-537AA) |
| Specificity | KAT2A antibody detects endogenous level of KAT2A protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
Related Products
-
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page -
417.46 $ – 242.68 $Buy now This product has multiple variants. The options may be chosen on the product page