Anti-KHDRBS3 Antibody
389.62 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human testis tissue with rabbit anti-KHDRBS3 antibody IGX-42553
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Catalog No
IGX-42553
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5′-[AU]UAAA-3′ motif in vitro. Binds optimally to RNA containing 5′-[AU]UAA-3′ as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PMID:10564820, PMID:19561594, PMID:26758068). Involved in splice site selection of vascular endothelial growth factor (PMID:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer . Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PMID:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity . May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing . Can bind FABP9 mRNA . May play a role as a negative regulator of cell growth. Inhibits cell proliferation. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 3 protein (177-346AA) |
| Specificity | KHDRBS3 antibody detects endogenous level of KHDRBS3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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