Anti-KIF14 Antibody
419.18 $ – 243.68 $
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue with rabbit anti-KIF14 antibody IGX-44364 at dilution 1:100.
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Catalog No
IGX-44364
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity . Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PMID:24784001, PMID:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PMID:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PMID:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PMID:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division . Also is required for chromosome congression and alignment during mitotic cell cycle process (PMID:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PMID:23209302). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Kinesin-like protein KIF14 protein (261-531AA) |
| Specificity | KIF14 antibody detects endogenous level of KIF14 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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