Anti-KMT5B Antibody
418.43 $ – 243.25 $
Western Blot
analysis of HL60 whole cell lysate
All lanes: KMT5B antibody at 3µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-49426
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Histone methyltransferase that specifically methylates monomethylated ‘Lys-20’ (H4K20me1) and dimethylated ‘Lys-20’ (H4K20me2) of histone H4 to produce respectively dimethylated ‘Lys-20’ (H4K20me2) and trimethylated ‘Lys-20’ (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PMID:24396869, PMID:28114273). In vitro also methylates unmodified ‘Lys-20’ (H4K20me0) of histone H4 and nucleosomes (PMID:24396869). H4 ‘Lys-20’ trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) . Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PMID:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of ‘Lys-20’ of histone H4 (PMID:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of ‘Lys-20’ of histone H4 . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB |
| Recommended Dilutions | WB: 1:500-1:5000 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Histone-lysine N-methyltransferase KMT5B protein (100-150AA) |
| Specificity | KMT5B antibody detects endogenous level of KMT5B protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
Related Products
-
418.43 $ – 243.25 $Buy now This product has multiple variants. The options may be chosen on the product page -
418.43 $ – 243.25 $Buy now This product has multiple variants. The options may be chosen on the product page -
418.43 $ – 243.25 $Buy now This product has multiple variants. The options may be chosen on the product page -
418.43 $ – 243.25 $Buy now This product has multiple variants. The options may be chosen on the product page