Anti-LAMP2 Antibody
419.18 $ – 243.68 $
Western Blot
analysis of Mouse spleen tissue, Mouse kidney tissue, Mouse brain tissue
All lanes: LAMP2 antibody at 4µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-48949
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PMID:8662539, PMID:11082038, PMID:18644871, PMID:24880125, PMID:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PMID:8662539, PMID:11082038, PMID:18644871, PMID:24880125). Plays a role in lysosomal protein degradation in response to starvation . Required for the fusion of autophagosomes with lysosomes during autophagy (PMID:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PMID:27628032). Required for normal degradation of the contents of autophagosomes (PMID:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PMID:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PMID:20518820). Isoform LAMP-2C: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Lysosome-associated membrane glycoprotein 2 protein (54-268AA) |
| Specificity | LAMP2 antibody detects endogenous level of LAMP2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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