Anti-LEF1 Antibody
419.42 $ – 243.82 $
IHC staining of paraffin-embedded Human tonsil tissue
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Catalog No
IGX-54532
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Transcription factor that binds DNA in a sequence-specific manner (PMID:2010090). Participates in the Wnt signaling pathway . Activates transcription of target genes in the presence of CTNNB1 and EP300 . PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 . TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PMID:11266540). Regulates T-cell receptor alpha enhancer function (PMID:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression . May play a role in hair cell differentiation and follicle morphogenesis . Isoform 1: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. Isoform 3: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. Isoform 5: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA: 1:1000-1:2000, IHC: 1:25-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human LEF1 |
| Specificity | LEF1 antibody detects endogenous level of LEF1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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