Anti-LGALS9 Antibody
391.32 $ – 243.74 $
Western blot
All lanes: LGALS9 antibody at 14µg/mL
Lane 1: HeLa whole cell lysate
Lane 2: Jurkat whole cell lysate
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Catalog No
IGX-49090
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Binds galactosides (PMID:18005988). Has high affinity for the Forssman pentasaccharide (PMID:18005988). Ligand for HAVCR2/TIM3 (PMID:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PMID:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth . Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PMID:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function . Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PMID:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PMID:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PMID:24465902, PMID:16116184). Inhibits degranulation and induces apoptosis of mast cells (PMID:24465902). Induces maturation and migration of dendritic cells (PMID:25754930, PMID:16116184). Inhibits natural killer (NK) cell function (PMID:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PMID:25578313). Astrocyte derived galectin-9 enhances microglial TNF production . May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion . Highly selective to the anion urate . Isoform 2: Acts as an eosinophil chemoattractant (PMID:9642261). It also inhibits angiogenesis (PMID:24333696). Suppresses IFNG production by natural killer cells . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Galectin-9 protein (1-240AA) |
| Specificity | LGALS9 antibody detects endogenous level of LGALS9 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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